Assessment of mutagenic and genotoxic activity of Caesalpinia sappan L. extract by Ames test and micronucleus assay
نویسندگان
چکیده
منابع مشابه
Genotoxicity assessment of Elaeagnus angustifolia L. fruit extract (senjed) nanocapsule by in vitro and in vivo methods
Background: Although initial studies on Elaeagnus Angustifolia L. Fruit Extract (Senjed) Nanocapsule showed its efficacy in osteoporosis in rat model as well as its significant role in elevating the serum calcium levels, there is no study on its possible genotixic potentials which is necessary for developing all nanopharmaceuticals. Objective: This study aimed to evaluate the genotoxicity of Se...
متن کاملMutagenic and antimutagenic effects of the traditional herb used for treating erectile dysfunction, Butea superba Roxb.
Butea superba is a traditional tuberous Thai plant enriched with flavonoids that is used for treating erectile dysfunction. We investigated the mutagenic and antimutagenic potentials of a B. superba extract by using the pre-incubation method of the Ames test. Salmonella typhimurium strains TA 98 and TA 100 were applied as the tester strains in the presence and absence of an S9 mixture. Prior to...
متن کاملAssessment of the Genotoxic Activity of Α-asarone and Its Derivatives in the Comet Assay
In our previous paper we examined mutagenic and genotoxic activity of 4 α-asarone isomers 2-5 exhibiting relatively high hypolipidemic activity. In the present paper, we examined genotoxic activity of αasarone and its isomers as the ability to damage cellular DNA, evaluated in the comet assay. Additionally, mutagenic activity of α-asarone in Ames test has been examined. The Ames test for α-asar...
متن کاملEvaluation of Antioxidant and Anthelmintic Properties of Caesalpinia sappan L. Leaves
Caesalpinia sappan L. is a popular medicinal plant known to both the Ayurveda and Chinese traditional medicines since ancient time. The aim of this research was to study the qualitative phytochemistry and to determine the antioxidant and anthelmintic activities of C. sappan leaves. Phytochemical analysis indicated the presence of various plant bioactive metabolites in C. sappan leaves. Differen...
متن کاملAmes Mutagenicity Assessment of Flavored Water Pipe Tobacco Products :A Cross Sectional Study in Tehran
Waterpipe smoking has become a global youth trend especially in the Middle East countries and Iran . The aim of this study was to determine the mutagenic effects of three most popular flavored tobaccos by four different salmonella typhimurium strains and compare the possible mutagenic effects of the test samples. Ames mutagenicity assessment was conducted according to the OECD guideline using T...
متن کامل